NRP1 Regulates CDC42 Activation to Promote Filopodia Formation in Endothelial Tip Cells
نویسندگان
چکیده
منابع مشابه
NRP1 Regulates CDC42 Activation to Promote Filopodia Formation in Endothelial Tip Cells
Sprouting blood vessels are led by filopodia-studded endothelial tip cells that respond to angiogenic signals. Mosaic lineage tracing previously revealed that NRP1 is essential for tip cell function, although its mechanistic role in tip cells remains poorly defined. Here, we show that NRP1 is dispensable for genetic tip cell identity. Instead, we find that NRP1 is essential to form the filopodi...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2015
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2015.05.018